Influenza, Immune System, and Pregnancy
Identifieur interne : 000705 ( Main/Exploration ); précédent : 000704; suivant : 000706Influenza, Immune System, and Pregnancy
Auteurs : Renju S. Raj [États-Unis] ; Elizabeth A. Bonney [États-Unis] ; Mark Phillippe [États-Unis]Source :
- Reproductive Sciences [ 1933-7191 ] ; 2014.
Abstract
Influenza is a major health problem worldwide. Both seasonal influenza and pandemics take a major toll on the health and economy of our country. The present review focuses on the virology and complex immunology of this RNA virus in general and in relation to pregnancy. The goal is to attempt to explain the increased morbidity and mortality seen in infection during pregnancy. We discuss elements of innate and adaptive immunity as well as placental cellular responses to infection. In addition, we delineate findings in animal models as well as human disease. Increased knowledge of maternal and fetal immunologic responses to influenza is needed. However, enhanced understanding of nonimmune, pregnancy-specific factors influencing direct interaction of the virus with host cells is also important for the development of more effective prevention and treatment options in the future.
Url:
DOI: 10.1177/1933719114537720
PubMed: 24899469
PubMed Central: 4231130
Affiliations:
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Raj</name><affiliation wicri:level="2"><nlm:aff id="aff1-1933719114537720">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT</wicri:regionArea><placeName><region type="state">Vermont</region></placeName></affiliation></author><author><name sortKey="Bonney, Elizabeth A" sort="Bonney, Elizabeth A" uniqKey="Bonney E" first="Elizabeth A." last="Bonney">Elizabeth A. 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